Reactome | phospho-p-Y700,Y731,Y774-CBL [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10075173] ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-912774] p(Y700,731,774)-CBL:CRK [cytosol] - Mus musculus [Complex:R-MMU-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] - Mus musculus [Complex:R-MMU-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-912790] CBL binds CRK - Mus musculus [Reaction:R-MMU-912727] CBL binds VAV - Mus musculus [Reaction:R-MMU-8848829] CBL autoubiquitinates - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10021582
displayName	phospho-p-Y700,Y731,Y774-CBL [cytosol]
endCoordinate	906
hasModifiedResidue	[ModifiedResidue:10021578] O4'-phospho-L-tyrosine at 731 (in Homo sapiens) [ModifiedResidue:10021579] O4'-phospho-L-tyrosine at 700 (in Homo sapiens) [ModifiedResidue:10021580] O4'-phospho-L-tyrosine at 774 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-912656] p-Y700,Y731,Y774-CBL [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-Y700,Y731,Y774-CBL P22682
producedByEvent	[Reaction:R-MMU-8848818] PTK6 phosphorylates CBL - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:P22682] UniProt:P22682 Cbl
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-912656
startCoordinate	1

(input)	[Reaction:R-MMU-912790] CBL binds CRK [Reaction:R-MMU-912727] CBL binds VAV [Reaction:R-MMU-8848829] CBL autoubiquitinates
(hasComponent)	[Complex:R-MMU-912774] p(Y700,731,774)-CBL:CRK [cytosol] [Complex:R-MMU-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-912755] p(Y700,731,774)-CBL:VAV1 [cytosol]
(physicalEntity)	[CatalystActivity:10075173] ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-912656] p-Y700,Y731,Y774-CBL [cytosol]
(output)	[Reaction:R-MMU-8848818] PTK6 phosphorylates CBL

Cite Us!