Reactome | Removal of Spo11 and Resection of 5' Ends of DNA

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Removal of Spo11 and Resection of 5' Ends of DNA Show undefined attributes

authored	[InstanceEdit:912374] May, B, 2010-07-02
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912369] May, B, 2010-07-08
dbId	912357
deleted	[Deleted:9032441] Deletion of instance: 912497 [Deleted:9032440] Deletion of instance: 5334727
displayName	Removal of Spo11 and Resection of 5' Ends of DNA
edited	[InstanceEdit:912374] May, B, 2010-07-02
followingEvent	[BlackBoxEvent:R-MMU-912421] Formation of Meiotic Single-stranded Invasion Complex - Mus musculus
input	[Complex:R-MMU-912419] Spo11:double-strand break [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:913291] Detection of SPO11-oligonucleotide complexes from mouse testes [LiteratureReference:913298] Endonucleolytic processing of covalent protein-linked DNA double-strand breaks [LiteratureReference:981766] The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Removal of Spo11 and Resection of 5' Ends of DNA
orthologousEvent	[BlackBoxEvent:R-HSA-9023943] MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end - Homo sapiens [BlackBoxEvent:R-HSA-9023941] MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 - Homo sapiens
output	[OtherEntity:R-ALL-75156] 3' overhanging DNA at resected DSB ends [nucleoplasm] [Complex:R-MMU-913214] Spo11:oligonucleotide [nucleoplasm]
precedingEvent	[Reaction:R-MMU-912344] Formation of Double-strand Break in DNA by Spo11 - Mus musculus
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-912357
summation	[Summation:913198] After cleaving DNA Spo11 remains covalently attached to the ...

Referrals

(replacementInstances)	[Deleted:9032441] Deletion of instance: 912497 [Deleted:9032440] Deletion of instance: 5334727
(precedingEvent)	[BlackBoxEvent:R-MMU-912421] Formation of Meiotic Single-stranded Invasion Complex

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