Reactome | MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end

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MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end Show undefined attributes

authored	[InstanceEdit:913923] May, B, 2010-07-19
catalystActivity	[CatalystActivity:981788] 3'-5'-DNA exonuclease activity of MRN:CtIP [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643714] 3'-5'-exodeoxyribonuclease activity of MRN:CtIP [nucleoplasm] The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9023944] May, Bruce, 2017-09-29
dbId	9023943
deleted	[Deleted:9023953] Deletion of instance: 912397
displayName	MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end
edited	[InstanceEdit:913923] May, B, 2010-07-19
eventOf	[Pathway:R-HSA-912446] Meiotic recombination - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-912357] Removal of Spo11 and Resection of 5' Ends of DNA - Mus musculus [BlackBoxEvent:R-SCE-981784] Removal of SPO11 and Resection of 5' Ends of DNA (yeast) - Saccharomyces cerevisiae
input	[Complex:R-HSA-9023945] SPO11:double strand break with 3' single strand breaks [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:913336] Human CtIP promotes DNA end resection
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end Removal of SPO11 and Resection of 5' Ends of DNA
output	[OtherEntity:R-ALL-75156] 3' overhanging DNA at resected DSB ends [nucleoplasm] [Complex:R-HSA-912381] SPO11:oligonucleotide [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9023941] MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 - Homo sapiens
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9023943
summation	[Summation:9023940] The MRN complex (MRE11:RAD50:NBS1:CtIP) exonucleolytically h...

Referrals

(replacementInstances)	[Deleted:9023953] Deletion of instance: 912397
(hasEvent)	[Pathway:R-HSA-912446] Meiotic recombination
(precedingEvent)	[BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex
(inferredTo)	[BlackBoxEvent:R-MMU-912357] Removal of Spo11 and Resection of 5' Ends of DNA [BlackBoxEvent:R-SCE-981784] Removal of SPO11 and Resection of 5' Ends of DNA (yeast)

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