Reactome | Signaling by NOTCH4

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Signaling by NOTCH4 Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03 [InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
created	[InstanceEdit:9013701] Orlic-Milacic, Marija, 2017-07-25
dbId	9013694
deleted	[Deleted:9608088] Deletion of instance: 1980150
displayName	Signaling by NOTCH4
doi	10.3180/R-HSA-9013694.1
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
figure	[Figure:2291908] /figures/Pathway_Illustrations/NOTCH4_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus - Homo sapiens [Pathway:R-HSA-9013695] NOTCH4 Intracellular Domain Regulates Transcription - Homo sapiens [Pathway:R-HSA-9604323] Negative regulation of NOTCH4 signaling - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9604023] Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors [LiteratureReference:9604031] Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells [LiteratureReference:157003] Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene [LiteratureReference:9604195] Notch signaling in primary endothelial cells [LiteratureReference:9604193] Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression [LiteratureReference:9604211] Notch4 reveals a novel mechanism regulating Notch signal transduction [LiteratureReference:9604235] Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors [LiteratureReference:9604423] Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis [LiteratureReference:9604426] Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes [LiteratureReference:9604524] Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity [LiteratureReference:9604560] The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma [LiteratureReference:9604577] Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors [LiteratureReference:9604688] Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium [LiteratureReference:9604811] Notch4 promotes gastric cancer growth through activation of Wnt1/?-catenin signaling [LiteratureReference:9604821] Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways [LiteratureReference:9604939] Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-? signalling pathway [LiteratureReference:9604945] An Epstein-Barr virus protein interacts with Notch [LiteratureReference:9604291] Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function [LiteratureReference:9013630] Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling [LiteratureReference:9604432] Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh) [LiteratureReference:9604316] AKT and 14-3-3 regulate Notch4 nuclear localization [LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis [LiteratureReference:9604663] Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site [LiteratureReference:9604588] Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development [LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation [LiteratureReference:9605452] Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis [LiteratureReference:9605461] The ANK repeats of Notch-4/Int3 activate NF-?B canonical pathway in the absence of Rbpj and causes mammary tumorigenesis
maxDepth	3
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Signaling by NOTCH4
orthologousEvent	[Pathway:R-RNO-9013694] Signaling by NOTCH4 - Rattus norvegicus [Pathway:R-BTA-9013694] Signaling by NOTCH4 - Bos taurus [Pathway:R-SSC-9013694] Signaling by NOTCH4 - Sus scrofa [Pathway:R-DRE-9013694] Signaling by NOTCH4 - Danio rerio [Pathway:R-DME-9013694] Signaling by NOTCH4 - Drosophila melanogaster [Pathway:R-MMU-9013694] Signaling by NOTCH4 - Mus musculus
releaseDate	2005-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:9608066] Haw, Robin, 2018-05-01
revised	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013694
summation	[Summation:9604025] The NOTCH4 gene locus was discovered as a frequent site of i...

Referrals

(hasEvent)	[Pathway:R-HSA-157118] Signaling by NOTCH
(hasEncapsulatedEvent)	[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
(replacementInstances)	[Deleted:9608088] Deletion of instance: 1980150

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