Reactome | HSPG binds LPL dimer

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HSPG binds LPL dimer Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065471
displayName	HSPG binds LPL dimer
eventOf	[Pathway:R-MMU-8963889] Assembly of active LPL and LIPC lipase complexes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6784628] PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer - Mus musculus [Reaction:R-MMU-8857928] GPIHBP1 binds HSPG:LPL dimer - Mus musculus
inferredFrom	[Reaction:R-HSA-6784861] HSPG binds LPL dimer - Homo sapiens
input	[SimpleEntity:R-ALL-1678620] HSPG [plasma membrane] [Complex:R-MMU-174592] LPL dimer [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HSPG binds LPL dimer
output	[Complex:R-MMU-8867477] HSPG:LPL dimer [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6784861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963889] Assembly of active LPL and LIPC lipase complexes
(precedingEvent)	[Reaction:R-MMU-6784628] PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer [Reaction:R-MMU-8857928] GPIHBP1 binds HSPG:LPL dimer
(inferredTo)	[Reaction:R-HSA-6784861] HSPG binds LPL dimer