Reactome | CK2 phosphorylates Nrf2

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CK2 phosphorylates Nrf2 Show undefined attributes

authored	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
catalystActivity	[CatalystActivity:8932321] protein serine/threonine kinase activity of CK2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644051] protein serine/threonine kinase activity of CK2 [cytosol] Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
dbId	8932375
displayName	CK2 phosphorylates Nrf2
edited	[InstanceEdit:9716626] Stephan, Ralf, 2021-02-23
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-8932335] Nfe2l2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932340] Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
maxDepth	1
modified	[InstanceEdit:9841062] Tiwari, Krishna, 2023-08-08
name	CK2 phosphorylates Nrf2
orthologousEvent	[BlackBoxEvent:R-HSA-8932322] CK2 phosphorylates NFE2L2 - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-8932371] p-Nfe2l2 [cytosol]
regulatedBy	[PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
regulationReference	[RegulationReference:9708471] Positive regulation by 'ROS [cytosol]' Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8932375
summation	[Summation:8932323] Upon stimulation by oxidative/electrophilic stress, Nuclear ...
updateTrackers	[UpdateTracker:9775230] Update Tracker - [BlackBoxEvent:8932375] CK2 phosphorylates Nrf2 - v80:[modifyText]

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[UpdateTracker:9775230] Update Tracker - [BlackBoxEvent:8932375] CK2 phosphorylates Nrf2 - v80:[modifyText]

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