Reactome | CK2 phosphorylates NFE2L2

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CK2 phosphorylates NFE2L2 Show undefined attributes

authored	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
catalystActivity	[CatalystActivity:8850941] protein serine/threonine kinase activity of Casein kinase II [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
dbId	8932322
displayName	CK2 phosphorylates NFE2L2
edited	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8932309] NFE2L2 translocates from cytosol to nucleoplasm - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-8932375] CK2 phosphorylates Nrf2 - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-201566] NFE2L2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8932340] Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells [LiteratureReference:8932305] Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
maxDepth	1
modified	[InstanceEdit:9841062] Tiwari, Krishna, 2023-08-08
name	CK2 phosphorylates NFE2L2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-8932311] p-S,T-NFE2L2 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9762100] MYC- and NICD1-dependent NFE2L2 gene expression - Homo sapiens
regulatedBy	[PositiveRegulation:9665172] Positive regulation by 'ROS [cytosol]'
regulationReference	[RegulationReference:9708471] Positive regulation by 'ROS [cytosol]' Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8932322
summation	[Summation:8932323] Upon stimulation by oxidative/electrophilic stress, Nuclear ...
updateTrackers	[UpdateTracker:9775008] Update Tracker - [BlackBoxEvent:8932322] CK2 phosphorylates NFE2L2 - v80:[add_removeInput, modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775008] Update Tracker - [BlackBoxEvent:8932322] CK2 phosphorylates NFE2L2 - v80:[add_removeInput, modifyText, removeOutput]
(hasEvent)	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[BlackBoxEvent:R-HSA-8932309] NFE2L2 translocates from cytosol to nucleoplasm
(inferredTo)	[BlackBoxEvent:R-MMU-8932375] CK2 phosphorylates Nrf2