Reactome | CK2 phosphorylates Nrf2

CK2 phosphorylates Nrf2

Stable Identifier

R-MMU-8932375

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol

ReviewStatus

5/5

General

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Upon stimulation by oxidative/electrophilic stress, Nuclear factor erythroid 2-related NFE2L2 (NRF2) is phosphorylated at the transcription activation domain (TA) by Casein kinase 2 (CK2). Deletional analysis revealed the transcription activation domains Neh4 (Nrf2-ECH homology 4) and Neh5 (Nrf2-ECH homology 5) as major regions necessary for the phosphorylation. The phosphorylation of these sites correlates with NFE2L2 translocation into the nucleus and this translocation is reduced in the presence of a CK2 inhibitor (Apopa et al. 2008, Pi et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18273910	Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells Apopa, PL, He, X, Ma, Q	J. Biochem. Mol. Toxicol.	2008

Participants

Input

Output

Catalyst Activity

protein serine/threonine kinase activity of CK2 [cytosol]

Physical Entity

CK2 [cytosol] (Mus musculus)

Activity

protein serine/threonine kinase activity (GO:0004674)

This event is regulated

Positively by

Regulator

ROS [cytosol]

Orthologous Events

CK2 phosphorylates NFE2L2 (Homo sapiens)

Authored

Garapati, P V (2016-07-22)

Reviewed

Somers, J (2021-01-23)

Created

Garapati, P V (2016-07-22)

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