Reactome | SHC1 in the RET complex is phosphorylated

Schema > BlackBoxEvent > Entries

SHC1 in the RET complex is phosphorylated Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10076684
displayName	SHC1 in the RET complex is phosphorylated
eventOf	[Pathway:R-MMU-8853659] RET signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-8853793] p-5Y-RET complexes bind GRB2 - Mus musculus [Reaction:R-MMU-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-8854981] SHC1 in the RET complex is phosphorylated - Homo sapiens
input	[Complex:R-MMU-8854400] 2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SHC1 in the RET complex is phosphorylated
output	[Complex:R-MMU-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-8854981
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8853659] RET signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-8853793] p-5Y-RET complexes bind GRB2 [Reaction:R-MMU-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
(inferredTo)	[BlackBoxEvent:R-HSA-8854981] SHC1 in the RET complex is phosphorylated

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