Reactome | Insulin:p-6Y-Insulin receptor [plasma membrane]

Schema > Complex > Entries

candidateOf	[CandidateSet:R-MMU-8857936] Activated SRC,LCK,EGFR,INSR [plasma membrane] - Mus musculus
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-MMU-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-110011] Binding of Grb10 to the insulin receptor - Mus musculus [Reaction:R-MMU-74707] Binding of IRS to insulin receptor - Mus musculus [Reaction:R-MMU-74740] Binding of SHC1 to insulin receptor - Mus musculus [BlackBoxEvent:R-MMU-74718] Internalisation of the insulin receptor - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9988981
displayName	Insulin:p-6Y-Insulin receptor [plasma membrane]
hasComponent	[Complex:R-MMU-74674] Insulin [extracellular region] [Complex:R-MMU-74671] p-6Y-insulin receptor [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-74678] Insulin:p-6Y-Insulin receptor [plasma membrane] - Homo sapiens
maxDepth	4
name	Insulin:p-6Y-Insulin receptor
producedByEvent	[Reaction:R-MMU-74712] Dissociation of IRS-P from insulin receptor - Mus musculus [Reaction:R-MMU-74743] Dissociation of p-Y427-SHC1 from insulin receptor - Mus musculus [Reaction:R-MMU-74715] Autophosphorylation of insulin receptor - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-74678
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-MMU-110011] Binding of Grb10 to the insulin receptor [Reaction:R-MMU-74707] Binding of IRS to insulin receptor [Reaction:R-MMU-74740] Binding of SHC1 to insulin receptor [BlackBoxEvent:R-MMU-74718] Internalisation of the insulin receptor
(hasCandidate)	[CandidateSet:R-MMU-8857936] Activated SRC,LCK,EGFR,INSR [plasma membrane]
(output)	[Reaction:R-MMU-74712] Dissociation of IRS-P from insulin receptor [Reaction:R-MMU-74743] Dissociation of p-Y427-SHC1 from insulin receptor [Reaction:R-MMU-74715] Autophosphorylation of insulin receptor
(hasComponent)	[Complex:R-MMU-74681] Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] [Complex:R-MMU-74685] Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] [Complex:R-MMU-110010] GRB10:INSR [plasma membrane] [Complex:R-MMU-74699] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] [Complex:R-MMU-74695] p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane]
(inferredTo)	[Complex:R-HSA-74678] Insulin:p-6Y-Insulin receptor [plasma membrane]

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