Reactome | Internalisation of the insulin receptor

Schema > BlackBoxEvent > Entries

Internalisation of the insulin receptor Show undefined attributes

category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9989046
displayName	Internalisation of the insulin receptor
eventOf	[Pathway:R-MMU-74752] Signaling by Insulin receptor - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-74726] Dissociation of insulin from insulin receptor - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:172011] receptor internalization
inferredFrom	[BlackBoxEvent:R-HSA-74718] Internalisation of the insulin receptor - Homo sapiens
input	[Complex:R-MMU-74678] Insulin:p-6Y-Insulin receptor [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Internalisation of the insulin receptor
output	[Complex:R-MMU-74702] Insulin:p-6Y-insulin receptor [endosome membrane]
precedingEvent	[Reaction:R-MMU-74715] Autophosphorylation of insulin receptor - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-74718
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-74752] Signaling by Insulin receptor
(inferredTo)	[BlackBoxEvent:R-HSA-74718] Internalisation of the insulin receptor
(precedingEvent)	[Reaction:R-MMU-74726] Dissociation of insulin from insulin receptor

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