Reactome | Dissociation of p-Y427-SHC1 from insulin receptor

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Dissociation of p-Y427-SHC1 from insulin receptor Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9989264
displayName	Dissociation of p-Y427-SHC1 from insulin receptor
eventOf	[Pathway:R-MMU-74751] Insulin receptor signalling cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Mus musculus
inferredFrom	[Reaction:R-HSA-74743] Dissociation of p-Y427-SHC1 from insulin receptor - Homo sapiens
input	[Complex:R-MMU-74685] Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dissociation of p-Y427-SHC1 from insulin receptor
output	[Complex:R-MMU-74678] Insulin:p-6Y-Insulin receptor [plasma membrane] [EntityWithAccessionedSequence:R-MMU-74684] phospho-Shc1 [cytosol]
precedingEvent	[Reaction:R-MMU-74742] Phosphorylation of SHC1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-74743
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-74751] Insulin receptor signalling cascade
(precedingEvent)	[Reaction:R-MMU-74746] GRB2-1:SOS1 binds p-Y427-SHC1
(inferredTo)	[Reaction:R-HSA-74743] Dissociation of p-Y427-SHC1 from insulin receptor

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