Reactome | Cap-dependent Translation Initiation

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Cap-dependent Translation Initiation Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098607
displayName	Cap-dependent Translation Initiation
eventOf	[Pathway:R-MMU-72613] Eukaryotic Translation Initiation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-MMU-72689] Formation of a pool of free 40S subunits - Mus musculus [Pathway:R-MMU-72695] Formation of the ternary complex, and subsequently, the 43S complex - Mus musculus [Pathway:R-MMU-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Mus musculus [Pathway:R-MMU-72702] Ribosomal scanning and start codon recognition - Mus musculus [Pathway:R-MMU-72706] GTP hydrolysis and joining of the 60S ribosomal subunit - Mus musculus [Pathway:R-MMU-72731] Recycling of eIF2:GDP - Mus musculus
inferredFrom	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Cap-dependent Translation Initiation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-72737
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-72613] Eukaryotic Translation Initiation
(inferredTo)	[Pathway:R-HSA-72737] Cap-dependent Translation Initiation

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