Reactome | BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA

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BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA Show undefined attributes

catalystActivity	[CatalystActivity:9987044] gamma-butyrobetaine dioxygenase activity of BBOX1:AscH-:Fe2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9987046
displayName	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA
eventOf	[Pathway:R-MMU-71262] Carnitine synthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-31369] TEABT [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA 2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate gamma-butyrobetaine + alpha-ketoglutarate + O2 => carnitine + succinate + CO2
output	[SimpleEntity:R-ALL-30235] CAR [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29434] SUCCA [cytosol]
precedingEvent	[Reaction:R-MMU-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-71261
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-71262] Carnitine synthesis
(inferredTo)	[Reaction:R-HSA-71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA

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