Reactome | Activation of the pre-replicative complex

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Activation of the pre-replicative complex Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098391
displayName	Activation of the pre-replicative complex
eventOf	[Pathway:R-MMU-69002] DNA Replication Pre-Initiation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-68952] DNA replication initiation - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:7971] DNA replication initiation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-68919] Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 - Mus musculus [Reaction:R-MMU-68940] Cdt1 is displaced from the pre-replicative complex - Mus musculus [Reaction:R-MMU-69299] CDT1 binds geminin - Mus musculus [Reaction:R-MMU-68918] CDK and DDK associate with the Mcm10:pre-replicative complex - Mus musculus [Reaction:R-MMU-68954] Mcm2-7 is phosphorylated by DDK - Mus musculus [Reaction:R-MMU-68917] Cdc45 associates with the pre-replicative complex at the origin - Mus musculus [Reaction:R-MMU-68916] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin - Mus musculus [Reaction:R-MMU-68914] DNA polymerase alpha:primase binds at the origin - Mus musculus [Reaction:R-MMU-68960] DNA polymerase epsilon binds at the origin - Mus musculus
inferredFrom	[Pathway:R-HSA-68962] Activation of the pre-replicative complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of the pre-replicative complex
precedingEvent	[Pathway:R-MMU-68867] Assembly of the pre-replicative complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-68962
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-MMU-68952] DNA replication initiation
(hasEvent)	[Pathway:R-MMU-69206] G1/S Transition [Pathway:R-MMU-69002] DNA Replication Pre-Initiation
(inferredTo)	[Pathway:R-HSA-68962] Activation of the pre-replicative complex