Reactome | DNA replication initiation

Schema > Pathway > Entries

DNA replication initiation Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098381
displayName	DNA replication initiation
eventOf	[Pathway:R-MMU-69239] Synthesis of DNA - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-69052] Switching of origins to a post-replicative state - Mus musculus [Pathway:R-MMU-68949] Orc1 removal from chromatin - Mus musculus [Pathway:R-MMU-69017] CDK-mediated phosphorylation and removal of Cdc6 - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:7971] DNA replication initiation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin - Mus musculus [Reaction:R-MMU-68950] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin - Mus musculus
inferredFrom	[Pathway:R-HSA-68952] DNA replication initiation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	DNA replication initiation
precedingEvent	[Pathway:R-MMU-68962] Activation of the pre-replicative complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-68952
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69239] Synthesis of DNA
(precedingEvent)	[Pathway:R-MMU-69052] Switching of origins to a post-replicative state [Pathway:R-MMU-68949] Orc1 removal from chromatin [Pathway:R-MMU-69017] CDK-mediated phosphorylation and removal of Cdc6
(inferredTo)	[Pathway:R-HSA-68952] DNA replication initiation