Reactome | Cdc45 associates with the pre-replicative complex at the origin

Schema > Reaction > Entries

Cdc45 associates with the pre-replicative complex at the origin Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9985313
displayName	Cdc45 associates with the pre-replicative complex at the origin
eventOf	[Pathway:R-MMU-68962] Activation of the pre-replicative complex - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-68916] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin - Mus musculus
inferredFrom	[Reaction:R-HSA-68917] Cdc45 associates with the pre-replicative complex at the origin - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-68563] Cdc45 [nucleoplasm] [Complex:R-MMU-68561] CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cdc45 associates with the pre-replicative complex at the origin
output	[Complex:R-MMU-68564] CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-68918] CDK and DDK associate with the Mcm10:pre-replicative complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-68917
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-68962] Activation of the pre-replicative complex
(precedingEvent)	[Reaction:R-MMU-68916] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
(inferredTo)	[Reaction:R-HSA-68917] Cdc45 associates with the pre-replicative complex at the origin

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