Reactome | CDK-mediated phosphorylation and removal of Cdc6

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CDK-mediated phosphorylation and removal of Cdc6 Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098401
displayName	CDK-mediated phosphorylation and removal of Cdc6
eventOf	[Pathway:R-MMU-69052] Switching of origins to a post-replicative state - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-69005] Cdc6 protein is phosphorylated by CDK - Mus musculus [Reaction:R-MMU-69006] Phosphorylated Cdc6 is exported from the nucleus - Mus musculus [Reaction:R-MMU-69015] Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex - Mus musculus [BlackBoxEvent:R-MMU-69016] Ubiquitinated Cdc6 is degraded by the proteasome - Mus musculus
inferredFrom	[Pathway:R-HSA-69017] CDK-mediated phosphorylation and removal of Cdc6 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CDK-mediated phosphorylation and removal of Cdc6
precedingEvent	[Pathway:R-MMU-68952] DNA replication initiation - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-69017
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69052] Switching of origins to a post-replicative state
(inferredTo)	[Pathway:R-HSA-69017] CDK-mediated phosphorylation and removal of Cdc6

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