Reactome | MTHFD1L transforms 10-formyl-THF to HCOOH and THF

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MTHFD1L transforms 10-formyl-THF to HCOOH and THF Show undefined attributes

catalystActivity	[CatalystActivity:10064489] formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10070714
displayName	MTHFD1L transforms 10-formyl-THF to HCOOH and THF
eventOf	[Pathway:R-MMU-196757] Metabolism of folate and pterines - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF - Homo sapiens
input	[SimpleEntity:R-ALL-5389850] 10-formyl-THF [mitochondrial matrix] [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFD1L transforms 10-formyl-THF to HCOOH and THF
output	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-6801451] HCOOH [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-6801462] MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6801456
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196757] Metabolism of folate and pterines
(inferredTo)	[Reaction:R-HSA-6801456] MTHFD1L transforms 10-formyl-THF to HCOOH and THF

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