Reactome | gp130:JAKs bind CNTFR

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065301
displayName	gp130:JAKs bind CNTFR
eventOf	[Pathway:R-MMU-6788467] IL-6-type cytokine receptor ligand interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6783530] gp130:JAKs bind CNTFR - Homo sapiens
input	[DefinedSet:R-MMU-6783659] CNTF:CNTFR,CRLF1:CLCF1:CNTFR [plasma membrane] [Complex:R-MMU-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	gp130:JAKs bind CNTFR
output	[Complex:R-MMU-6783658] CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6783530
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-6788467] IL-6-type cytokine receptor ligand interactions
(inferredTo)	[Reaction:R-HSA-6783530] gp130:JAKs bind CNTFR