Reactome | PIAS4 SUMOylates MDC1

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PIAS4 SUMOylates MDC1 Show undefined attributes

catalystActivity	[CatalystActivity:10060699] SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060701
displayName	PIAS4 SUMOylates MDC1
eventOf	[Pathway:R-MMU-5693607] Processing of DNA double-strand break ends - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5684071] RNF4 ubiquitinates MDC1 - Mus musculus
inferredFrom	[Reaction:R-HSA-5684052] PIAS4 SUMOylates MDC1 - Homo sapiens
input	[Complex:R-MMU-5683808] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] 4 × [Complex:R-MMU-2993778] SUMO2:UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PIAS4 SUMOylates MDC1
output	[Complex:R-MMU-5684053] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] 4 × [EntityWithAccessionedSequence:R-MMU-912483] Ube2i [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5683801] CHEK2 phosphorylates BRCA1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5684052
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-MMU-5684071] RNF4 ubiquitinates MDC1
(inferredTo)	[Reaction:R-HSA-5684052] PIAS4 SUMOylates MDC1