Reactome | D-loop extension by DNA polymerases

Schema > Reaction > Entries

D-loop extension by DNA polymerases Show undefined attributes

catalystActivity	[CatalystActivity:10063394] DNA-directed DNA polymerase activity of PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10063396
displayName	D-loop extension by DNA polymerases
eventOf	[Pathway:R-MMU-5685942] HDR through Homologous Recombination (HRR) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-5693537] Resolution of D-Loop Structures - Mus musculus [BlackBoxEvent:R-MMU-5693539] Ligation of DNA and formation of Holliday structures following repair synthesis - Mus musculus [Reaction:R-MMU-5686440] MUS81:EME1,EME2 cleaves D-loop - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:25131] DNA synthesis involved in DNA repair
inferredFrom	[Reaction:R-HSA-5693593] D-loop extension by DNA polymerases - Homo sapiens
input	[Complex:R-MMU-5685826] D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	D-loop extension by DNA polymerases
output	[Complex:R-MMU-5686104] Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5685838] CX3 complex binds D-loop structures - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5693593
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5685942] HDR through Homologous Recombination (HRR)
(precedingEvent)	[Pathway:R-MMU-5693537] Resolution of D-Loop Structures [Reaction:R-MMU-5686440] MUS81:EME1,EME2 cleaves D-loop [BlackBoxEvent:R-MMU-5693539] Ligation of DNA and formation of Holliday structures following repair synthesis
(inferredTo)	[Reaction:R-HSA-5693593] D-loop extension by DNA polymerases