Reactome | Ligation of DNA and formation of Holliday structures following repair synthesis

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Ligation of DNA and formation of Holliday structures following repair synthesis Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10063329
displayName	Ligation of DNA and formation of Holliday structures following repair synthesis
eventOf	[Pathway:R-MMU-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5693584] Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-5693539] Ligation of DNA and formation of Holliday structures following repair synthesis - Homo sapiens
input	[Complex:R-MMU-5686104] Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ligation of DNA and formation of Holliday structures following repair synthesis
output	[Complex:R-MMU-5686228] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5693593] D-loop extension by DNA polymerases - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5693539
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693568] Resolution of D-loop Structures through Holliday Junction Intermediates
(precedingEvent)	[Reaction:R-MMU-5693584] Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
(inferredTo)	[BlackBoxEvent:R-HSA-5693539] Ligation of DNA and formation of Holliday structures following repair synthesis

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