Reactome | PIAS4 SUMOylates MDC1

Schema > Reaction > Entries

PIAS4 SUMOylates MDC1 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5684057] SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684067] Orlic-Milacic, Marija, 2015-03-18
dbId	5684052
displayName	PIAS4 SUMOylates MDC1
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1 - Homo sapiens
input	[Complex:R-HSA-5683808] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] 4 × [Complex:R-HSA-2993778] SUMO2:UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4570503] Sumoylation of MDC1 is important for proper DNA damage response [LiteratureReference:5655625] SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PIAS4 SUMOylates MDC1
orthologousEvent	[Reaction:R-MMU-5684052] PIAS4 SUMOylates MDC1 - Mus musculus [Reaction:R-GGA-5684052] PIAS4 SUMOylates MDC1 - Gallus gallus [Reaction:R-DRE-5684052] PIAS4 SUMOylates MDC1 - Danio rerio [Reaction:R-SSC-5684052] PIAS4 SUMOylates MDC1 - Sus scrofa [Reaction:R-BTA-5684052] PIAS4 SUMOylates MDC1 - Bos taurus [Reaction:R-RNO-5684052] PIAS4 SUMOylates MDC1 - Rattus norvegicus
output	[Complex:R-HSA-5684053] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] 4 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5683801] CHEK2 phosphorylates BRCA1 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684052
summation	[Summation:5684060] PIAS4 SUMOylates MDC1 at lysine residue K1840. The exact tim...

Referrals

(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1