Reactome | p-CBL:GRB2 binds p-FRS2:activated FGFR2

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p-CBL:GRB2 binds p-FRS2:activated FGFR2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10058303
displayName	p-CBL:GRB2 binds p-FRS2:activated FGFR2
eventOf	[Pathway:R-MMU-5654727] Negative regulation of FGFR2 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5654677] CBL ubiquitinates FRS2 and FGFR2 - Mus musculus
inferredFrom	[Reaction:R-HSA-5654729] p-CBL:GRB2 binds p-FRS2:activated FGFR2 - Homo sapiens
input	[Complex:R-MMU-5654184] Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] [Complex:R-MMU-182964] p-Y371-CBL:GRB2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-CBL:GRB2 binds p-FRS2:activated FGFR2
output	[Complex:R-MMU-5654286] Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5654607] Activated FGFR2 phosphorylates PPTN11 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5654729
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-5654677] CBL ubiquitinates FRS2 and FGFR2
(hasEvent)	[Pathway:R-MMU-5654727] Negative regulation of FGFR2 signaling
(inferredTo)	[Reaction:R-HSA-5654729] p-CBL:GRB2 binds p-FRS2:activated FGFR2

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