Reactome | Negative regulation of FGFR2 signaling

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Negative regulation of FGFR2 signaling Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100519
displayName	Negative regulation of FGFR2 signaling
eventOf	[Pathway:R-MMU-5654738] Signaling by FGFR2 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5654562] Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 - Mus musculus [Reaction:R-MMU-5654729] p-CBL:GRB2 binds p-FRS2:activated FGFR2 - Mus musculus [Reaction:R-MMU-5654677] CBL ubiquitinates FRS2 and FGFR2 - Mus musculus [Pathway:R-MMU-1295596] Spry regulation of FGF signaling - Mus musculus
inferredFrom	[Pathway:R-HSA-5654727] Negative regulation of FGFR2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Negative regulation of FGFR2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5654727
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5654738] Signaling by FGFR2
(inferredTo)	[Pathway:R-HSA-5654727] Negative regulation of FGFR2 signaling

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