Smurf1/2 ubiquitinates Ptch1

Stable Identifier
R-MMU-5632644
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Smurf1/2 ubiquitinates Ptch1

Mouse Ptch1 is ubiquitinated on its C-terminal tail in a Smurf1/2-dependent manner. Smurf1/2-mediated ubiquitination is stimulated by SHH and results in downregulation of Ptch1 from the ciliary membrane to endocytic compartments for degradation (Yue et al, 2014).

Literature References
PubMed ID Title Journal Year
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, Cheng, SY

Elife 2014
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of Ptch1:Smurf1/2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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