Reactome | atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm]

Schema > Complex > Entries

atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5619371] May, Bruce, 2014-08-22
dbId	5619385
displayName	atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-MMU-556805] Ep300 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5619361] Hoxa4 gene [nucleoplasm] [Complex:R-MMU-5619354] Mll2,3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556815] Ncoa3 [nucleoplasm] [Complex:R-MMU-1214204] Nucleosome with H3K4me3 [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm] [Complex:R-MMU-5617958] Rxra:Rara,b:atRA [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-HSA-5617873] atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:5619229] Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning [LiteratureReference:5619158] Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element [LiteratureReference:5619269] Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron [LiteratureReference:5619306] HOXD4 and regulation of the group 4 paralog genes [LiteratureReference:5621541] Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development [LiteratureReference:5626755] KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development [LiteratureReference:5617912] Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts [LiteratureReference:5617928] Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells [LiteratureReference:5690634] Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II
maxDepth	5
modified	[InstanceEdit:6810175] May, Bruce, 2015-11-16
name	atRA:Rara,b:Rxra at active Hoxa4 chromatin
positivelyRegulates	[PositiveRegulation:R-MMU-5634082] Positive regulation by 'atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-MMU-5619434] Retinoic acid activates Hoxa4 chromatin - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-5619385
updateTrackers	[UpdateTracker:9897803] Update Tracker - [Complex:5619385] atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm] - v62:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9897803] Update Tracker - [Complex:5619385] atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm] - v62:[updateContainedComponent]
(regulator)	[PositiveRegulation:R-MMU-5634082] Positive regulation by 'atRA:Rara,b:Rxra at active Hoxa4 chromatin [nucleoplasm]'
(output)	[BlackBoxEvent:R-MMU-5619434] Retinoic acid activates Hoxa4 chromatin

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