Reactome | Retinoic acid activates Hoxa1 chromatin

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Retinoic acid activates Hoxa1 chromatin Show undefined attributes

authored	[InstanceEdit:5617898] May, Bruce, 2014-08-15 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617923] May, Bruce, 2014-08-16
dbId	5617990
displayName	Retinoic acid activates Hoxa1 chromatin
edited	[InstanceEdit:5621561] May, Bruce, 2014-08-31
followingEvent	[BlackBoxEvent:R-MMU-5617999] Hoxa1 gene is transcribed - Mus musculus
input	[SimpleEntity:R-ALL-5334804] atRA [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556805] Ep300 [nucleoplasm] [Complex:R-MMU-5619354] Mll2,3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556815] Ncoa3 [nucleoplasm] [Complex:R-MMU-5617939] Rarg:Rxra at Hoxa1 bivalent chromatin [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5617928] Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells [LiteratureReference:5617912] Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts [LiteratureReference:5617921] The retinol signaling pathway in mouse pluripotent P19 cells [LiteratureReference:5617996] Retinoids regulate stem cell differentiation [LiteratureReference:5617936] Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis [LiteratureReference:5617993] Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid [LiteratureReference:5618004] Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals [LiteratureReference:5617961] High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid [LiteratureReference:5617920] Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements [LiteratureReference:5619332] Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila [LiteratureReference:5619244] In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE) [LiteratureReference:5626755] KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development [LiteratureReference:5675587] Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells [LiteratureReference:5675590] Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling [LiteratureReference:5675600] Detection of targeted GFP-Hox gene fusions during mouse embryogenesis [LiteratureReference:5675603] Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex [LiteratureReference:5675596] Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain [LiteratureReference:5675625] Region-specific expression in early chick and mouse embryos of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial [LiteratureReference:5619504] Hox genes and segmentation of the hindbrain and axial skeleton [LiteratureReference:5687944] Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor [LiteratureReference:5687914] LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling [LiteratureReference:383069] A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors [LiteratureReference:5687966] Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6 [LiteratureReference:5690634] Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II [LiteratureReference:5687961] Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates Hoxa1 chromatin
orthologousEvent	[BlackBoxEvent:R-HSA-5617431] Retinoic acid activates HOXA1 chromatin - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-5687969] Ajuba [nucleoplasm] [Complex:R-MMU-5617976] atRA:Rara,g:Rxra at active Hoxa1 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-442520] Hdac3 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-442459] Ncor1 [nucleoplasm] [Complex:R-MMU-5617945] PRC2 (EZH2) [nucleoplasm]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5617990
summation	[Summation:5621003] Experiments in mouse embryos (Frasch et al. 1995, Dupe et al...

Referrals

(precedingEvent)

[BlackBoxEvent:R-MMU-5617999] Hoxa1 gene is transcribed

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