Reactome | Binding of Gbeta/gamma to GIRK/Kir3 channels

Schema > Reaction > Entries

Binding of Gbeta/gamma to GIRK/Kir3 channels Show undefined attributes

catalystActivity	[CatalystActivity:10028255] G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10028257
displayName	Binding of Gbeta/gamma to GIRK/Kir3 channels
eventOf	[Pathway:R-MMU-1296041] Activation of G protein gated Potassium channels - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1013020] Activation of GIRK/Kir3 Channels - Mus musculus
inferredFrom	[Reaction:R-HSA-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Homo sapiens
input	[Complex:R-MMU-1013017] GABA B receptor G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-MMU-975294] Kir heterotetramers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of Gbeta/gamma to GIRK/Kir3 channels
output	[Complex:R-MMU-1013011] GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]
precedingEvent	[Reaction:R-MMU-1013013] Association of GABA B receptor with G protein beta-gamma subunits - Mus musculus [Reaction:R-MMU-420688] GABAB heterodimeric receptor binds GABA - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1013012
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1296041] Activation of G protein gated Potassium channels [Pathway:R-MMU-997272] Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
(precedingEvent)	[Reaction:R-MMU-1013020] Activation of GIRK/Kir3 Channels
(inferredTo)	[Reaction:R-HSA-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels