Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100177
displayName	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
eventOf	[Pathway:R-MMU-373755] Semaphorin interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-399933] Sema3A binds Nrp-1 bound to PlexinA - Mus musculus [Reaction:R-MMU-399936] Inhibition of integrin activation by sequestering PIP5KIgamma - Mus musculus
inferredFrom	[Pathway:R-HSA-399955] SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-399955
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-373755] Semaphorin interactions
(inferredTo)	[Pathway:R-HSA-399955] SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

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