Reactome | Sema3A binds Nrp-1 bound to PlexinA

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Sema3A binds Nrp-1 bound to PlexinA Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10013713
displayName	Sema3A binds Nrp-1 bound to PlexinA
eventOf	[Pathway:R-MMU-399955] SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-399936] Inhibition of integrin activation by sequestering PIP5KIgamma - Mus musculus
inferredFrom	[Reaction:R-HSA-399933] Sema3A binds Nrp-1 bound to PlexinA - Homo sapiens
input	[Complex:R-MMU-399837] NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] [Complex:R-MMU-399861] Sema3A dimer [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Sema3A binds Nrp-1 bound to PlexinA
output	[EntityWithAccessionedSequence:R-MMU-396935] Farp2 [cytosol] [Complex:R-MMU-399858] Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-399933
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-399955] SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
(precedingEvent)	[Reaction:R-MMU-399936] Inhibition of integrin activation by sequestering PIP5KIgamma
(inferredTo)	[Reaction:R-HSA-399933] Sema3A binds Nrp-1 bound to PlexinA

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