Reactome | Rap1 signalling

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Rap1 signalling Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099971
displayName	Rap1 signalling
eventOf	[Pathway:R-MMU-1280218] Adaptive Immune System - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-913996] PKA/PKG phosphorylate Rap1GAP2 - Mus musculus [Reaction:R-MMU-913993] 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 - Mus musculus [Reaction:R-MMU-392834] Activation of EPACs by cAMP - Mus musculus [Reaction:R-MMU-939265] Activation of Rap1 by membrane-associated GEFs - Mus musculus [Reaction:R-MMU-354173] Activation of Rap1 by cytosolic GEFs - Mus musculus [Reaction:R-MMU-392513] Rap1 signal termination by Rap1GAPs - Mus musculus [Reaction:R-MMU-392835] Rap1 sequesters Raf1 to inhibit ERK cascade - Mus musculus
inferredFrom	[Pathway:R-HSA-392517] Rap1 signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Rap1 signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-392517
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1280218] Adaptive Immune System
(inferredTo)	[Pathway:R-HSA-392517] Rap1 signalling

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