Reactome | 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2

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14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10021856
displayName	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
eventOf	[Pathway:R-MMU-392517] Rap1 signalling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-392513] Rap1 signal termination by Rap1GAPs - Mus musculus
inferredFrom	[Reaction:R-HSA-913993] 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 - Homo sapiens
input	[DefinedSet:R-MMU-914001] 14-3-3 beta, zeta [cytosol] [EntityWithAccessionedSequence:R-MMU-392491] Rap1gap2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
output	[Complex:R-MMU-913992] RAP1GAP2:14-3-3beta, zeta [cytosol]
precedingEvent	[Reaction:R-MMU-913996] PKA/PKG phosphorylate Rap1GAP2 - Mus musculus
regulatedBy	[NegativeRegulation:10021857] Negative regulation by 'p-S7-RAP1GAP2 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-913993
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-392517] Rap1 signalling
(precedingEvent)	[Reaction:R-MMU-392513] Rap1 signal termination by Rap1GAPs
(inferredTo)	[Reaction:R-HSA-913993] 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2

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