Reactome | Activation of EPACs by cAMP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10013582
displayName	Activation of EPACs by cAMP
eventOf	[Pathway:R-MMU-392517] Rap1 signalling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-939265] Activation of Rap1 by membrane-associated GEFs - Mus musculus
inferredFrom	[Reaction:R-HSA-392834] Activation of EPACs by cAMP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-30389] cAMP [cytosol] [DefinedSet:R-MMU-392485] Rap1 cAMP-GEFs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of EPACs by cAMP
output	[Complex:R-MMU-392837] Rap1 cAMP-GEFs:cAMP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-392834
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-392517] Rap1 signalling
(precedingEvent)	[Reaction:R-MMU-939265] Activation of Rap1 by membrane-associated GEFs
(inferredTo)	[Reaction:R-HSA-392834] Activation of EPACs by cAMP

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