Reactome | phospho-p-Y397-PTK2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10095620] protein tyrosine kinase activity of p-Y397-PTK2 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-354135] Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] - Mus musculus [Complex:R-MMU-8874094] HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10008343
displayName	phospho-p-Y397-PTK2 [cytosol]
endCoordinate	1052
hasModifiedResidue	[ModifiedResidue:420338] O4'-phospho-L-tyrosine at 397
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-354068] p-Y397-PTK2 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-Y397-PTK2 P34152
positivelyRegulates	[PositiveRegulation:10095656] Positive regulation by 'p-Y397-PTK2 [cytosol]'
producedByEvent	[BlackBoxEvent:R-MMU-9861484] Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow - Mus musculus
referenceEntity	[ReferenceIsoform:uniprot:P34152-4] UniProt:P34152-4 Ptk2
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-354068
startCoordinate	2

(hasComponent)	[Complex:R-MMU-354135] Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] [Complex:R-MMU-8874094] HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] [Complex:R-MMU-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] [Complex:R-MMU-3928549] EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] [Complex:R-MMU-418822] NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] [Complex:R-MMU-418839] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] [Complex:R-MMU-5218639] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane]
(regulator)	[PositiveRegulation:10095656] Positive regulation by 'p-Y397-PTK2 [cytosol]'
(physicalEntity)	[CatalystActivity:10095620] protein tyrosine kinase activity of p-Y397-PTK2 [cytosol]
(output)	[BlackBoxEvent:R-MMU-9861484] Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-354068] p-Y397-PTK2 [cytosol]

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