Reactome | Cflar [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol] - Mus musculus [Complex:R-MMU-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] - Mus musculus [Complex:R-MMU-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-9796617] MIB2 binds CFLAR - Mus musculus [Reaction:R-MMU-3371359] FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling - Mus musculus [Reaction:R-MMU-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Mus musculus [Reaction:R-MMU-9794008] LUBAC binds CFLAR - Mus musculus [Reaction:R-MMU-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10048866
displayName	Cflar [cytosol]
endCoordinate	480
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-3371356] CFLAR(1-480) [cytosol] - Homo sapiens
maxDepth	1
name	Cflar CFLAR(1-480) O35732
referenceEntity	[ReferenceGeneProduct:uniprot:O35732] UniProt:O35732
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-3371356
startCoordinate	1

(input)	[Reaction:R-MMU-9794008] LUBAC binds CFLAR [Reaction:R-MMU-9796617] MIB2 binds CFLAR [Reaction:R-MMU-3371359] FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling [Reaction:R-MMU-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling [Reaction:R-MMU-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling
(hasComponent)	[Complex:R-MMU-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol] [Complex:R-MMU-9796628] CFLAR:MIB2:Ub:UBE2D1 [cytosol] [Complex:R-MMU-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] [Complex:R-MMU-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] [Complex:R-MMU-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Complex:R-MMU-3371381] DISC:procaspase-8:FLIP(L) [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-3371356] CFLAR(1-480) [cytosol]