Reactome | LUBAC binds CFLAR

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10093184
displayName	LUBAC binds CFLAR
eventOf	[Pathway:R-MMU-5357905] Regulation of TNFR1 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-9793988] LUBAC ubiquitinates CFLAR at K351, K353 - Mus musculus
inferredFrom	[Reaction:R-HSA-9794008] LUBAC binds CFLAR - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-3371356] Cflar [cytosol] [Complex:R-MMU-5357865] LUBAC [cytosol] [Complex:R-MMU-8938763] Ub:UBE2L3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LUBAC binds CFLAR LUBAC binds FLIP(L)
output	[Complex:R-MMU-9794013] CFLAR:LUBAC:Ub:UBE2D3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9794008
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-5357905] Regulation of TNFR1 signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-9793988] LUBAC ubiquitinates CFLAR at K351, K353
(inferredTo)	[Reaction:R-HSA-9794008] LUBAC binds CFLAR

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