Reactome | DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

Schema > Reaction > Entries

DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) Show undefined attributes

catalystActivity	[CatalystActivity:10057608] histone H3 methyltransferase activity of DOT1L [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057620
displayName	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)
eventOf	[Pathway:R-MMU-3214841] PKMTs methylate histone lysines - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5649799] DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-MMU-5649783] Me2K80-histone H3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) DOT1L (KMT4) methylates Me2K80-histone H3 (H3K79) DOT1L methylates dimethyl-lysine-80 of histone H3
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-MMU-5649777] Me3K80-histone H3 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5649799
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3214841] PKMTs methylate histone lysines
(inferredTo)	[Reaction:R-HSA-5649799] DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

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