Reactome | IRF3 mediated activation of type 1 IFN

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100857
displayName	IRF3 mediated activation of type 1 IFN
eventOf	[Pathway:R-MMU-1606322] ZBP1(DAI) mediated induction of type I IFNs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-2395992] p-T,4S-IRF3 is dimerized - Mus musculus [Reaction:R-MMU-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRF3 mediated activation of type 1 IFN
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-1606341
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-1606322] ZBP1(DAI) mediated induction of type I IFNs
(inferredTo)	[Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN

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