Reactome | phospho-p-S177,S181-IKBKB [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10006102] protein serine/threonine kinase activity of p-S177,S181-IKBKB [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-193888] Phospho-IKK-beta homdimer [cytosol] - Mus musculus [Complex:R-MMU-193888] Phospho-IKK-beta homdimer [cytosol] - Mus musculus [Complex:R-MMU-202562] CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] - Mus musculus [Complex:R-MMU-177663] IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9996852
displayName	phospho-p-S177,S181-IKBKB [cytosol]
endCoordinate	756
hasModifiedResidue	[ModifiedResidue:9996849] O-phospho-L-serine at 177 (in Homo sapiens) [ModifiedResidue:9996850] O-phospho-L-serine at 181 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-202506] p-S177,S181-IKBKB [cytosol] - Homo sapiens
maxDepth	1
name	phospho-p-S177,S181-IKBKB O88351
referenceEntity	[ReferenceGeneProduct:uniprot:O88351] UniProt:O88351
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-202506
startCoordinate	1

(hasComponent)	[Complex:R-MMU-193888] Phospho-IKK-beta homdimer [cytosol] [Complex:R-MMU-202562] CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] [Complex:R-MMU-177663] IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] [Complex:R-MMU-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
(activeUnit)	[CatalystActivity:10004572] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] [CatalystActivity:9996855] protein serine/threonine kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] [CatalystActivity:10093107] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [CatalystActivity:10060770] IkappaB kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
(physicalEntity)	[CatalystActivity:10006102] protein serine/threonine kinase activity of p-S177,S181-IKBKB [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-202506] p-S177,S181-IKBKB [cytosol]