Reactome | Active ALK dimer [plasma membrane]

Schema > CandidateSet > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-MMU-9699995] Active ALK:PI3K [plasma membrane] - Mus musculus [Complex:R-MMU-9699992] Active ALK:p-4Y PLCG1 [plasma membrane] - Mus musculus
consumedByEvent	[BlackBoxEvent:R-MMU-201515] Active ALK recruits PI3K - Mus musculus [Reaction:R-MMU-9700156] Active ALK dimer binds IRS1 - Mus musculus [Reaction:R-MMU-9700154] Active ALK binds SHC1 - Mus musculus [Reaction:R-MMU-9701485] Active ALK binds JAK3 - Mus musculus [BlackBoxEvent:R-MMU-9701524] STAT3 is phosphorylated downstream of active ALK - Mus musculus [Reaction:R-MMU-9700149] Active ALK binds PLCG1 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10003755
displayName	Active ALK dimer [plasma membrane]
hasCandidate	[Complex:R-MMU-9700017] MDK:p-7Y ALK dimer [plasma membrane] - Mus musculus [Complex:R-MMU-201534] PTN:p-7Y ALK dimer [plasma membrane] - Mus musculus
hasMember	[Complex:R-MMU-9850880] p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] - Mus musculus
inDisease	false
inferredFrom	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane] - Homo sapiens
maxDepth	5
name	Active ALK dimer
producedByEvent	[Reaction:R-MMU-201521] ALK autophosphorylation - Mus musculus
schemaClass	CandidateSet
species	[Species:48892] Mus musculus
stId	R-MMU-9850879

(input)	[BlackBoxEvent:R-MMU-201515] Active ALK recruits PI3K [Reaction:R-MMU-9700149] Active ALK binds PLCG1 [Reaction:R-MMU-9700156] Active ALK dimer binds IRS1 [Reaction:R-MMU-9700154] Active ALK binds SHC1 [Reaction:R-MMU-9701485] Active ALK binds JAK3 [BlackBoxEvent:R-MMU-9701524] STAT3 is phosphorylated downstream of active ALK
(hasComponent)	[Complex:R-MMU-9699995] Active ALK:PI3K [plasma membrane] [Complex:R-MMU-9699992] Active ALK:p-4Y PLCG1 [plasma membrane] [Complex:R-MMU-9699982] Active ALK:PLCG1 [plasma membrane] [Complex:R-MMU-9699983] Active ALK:pY-IRS1 [plasma membrane] [Complex:R-MMU-9699993] Active ALK:IRS1 [plasma membrane] [Complex:R-MMU-9700011] Active ALK:p-3Y SHC1 [plasma membrane] [Complex:R-MMU-9699970] Active ALK:SHC1 [plasma membrane] [Complex:R-MMU-9701478] Active ALK:JAK3 [plasma membrane] [Complex:R-MMU-9701475] Active ALK:p-Y980 JAK3 [plasma membrane]
(output)	[Reaction:R-MMU-201521] ALK autophosphorylation
(inferredTo)	[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane]

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