Reactome | phospho-Foxo3 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[BlackBoxEvent:R-MMU-9699581] AKT-phosphorylated FOXO3 translocates to cytosol - Mus musculus [BlackBoxEvent:R-MMU-9624527] AKT-phosphorylated FOXO3 translocates to cytosol - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10003101
displayName	phospho-Foxo3 [nucleoplasm]
endCoordinate	673
hasModifiedResidue	[ModifiedResidue:10003097] O-phospho-L-serine at 253 (in Homo sapiens) [ModifiedResidue:10003098] O-phospho-L-serine at 315 (in Homo sapiens) [ModifiedResidue:10003099] O-phospho-L-threonine at 32 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-MMU-199269] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm] - Mus musculus
name	phospho-Foxo3 p-T32,S253,S315-FOXO3 Q9WVH4
producedByEvent	[Reaction:R-MMU-9699579] AKT phosphorylates FOXO3 downstream of FLT3 - Mus musculus [Reaction:R-MMU-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:Q9WVH4] UniProt:Q9WVH4 Foxo3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-199289
startCoordinate	2

(input)	[BlackBoxEvent:R-MMU-9699581] AKT-phosphorylated FOXO3 translocates to cytosol [BlackBoxEvent:R-MMU-9624527] AKT-phosphorylated FOXO3 translocates to cytosol
(output)	[Reaction:R-MMU-9699579] AKT phosphorylates FOXO3 downstream of FLT3 [Reaction:R-MMU-9624526] AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
(hasMember)	[DefinedSet:R-MMU-199269] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm] [CandidateSet:R-MMU-9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199289] p-T32,S253,S315-FOXO3 [nucleoplasm]

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