Reactome | SRC-2 [cytosol]

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SRC-2 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10009964] protein tyrosine kinase activity of SRC-1 [cytosol] [CatalystActivity:10082298] protein tyrosine kinase activity of SRC-1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-418179] F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] - Mus musculus [Complex:R-MMU-372650] FAK-SRC complex [plasma membrane] - Mus musculus [Complex:R-MMU-5218757] VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] - Mus musculus
consumedByEvent	[BlackBoxEvent:R-MMU-418662] Src activation following P2Y purinoceptor activation - Mus musculus [Reaction:R-MMU-5218645] SRC-1 binds p-Y397-PTK2 - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions - Mus musculus [Reaction:R-MMU-4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 - Mus musculus [BlackBoxEvent:R-MMU-443418] GP1b signaling involves c-Src - Mus musculus [Reaction:R-MMU-418170] F2R:ARRB1 binds MAPKs, SRC-1 - Mus musculus [Reaction:R-MMU-418176] F2R:ARRB2 binds MAPKs, SRC-1 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001058
displayName	SRC-2 [cytosol]
endCoordinate	536
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-418145] Activated SRC-1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-191648] SRC-2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-354153] SRC-1 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-MMU-1861597] Src family kinases (SFKs) [cytosol] - Mus musculus [DefinedSet:R-MMU-8855753] SRC-1, RAP1GAP [cytosol] - Mus musculus [DefinedSet:R-MMU-211064] Src family tyrosine kinases (SFKs) [cytosol] - Mus musculus
name	SRC-2 P05480
referenceEntity	[ReferenceGeneProduct:uniprot:P05480] UniProt:P05480 Src
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-191648
startCoordinate	2

Referrals

(hasComponent)	[Complex:R-MMU-372650] FAK-SRC complex [plasma membrane] [Complex:R-MMU-418210] F2R:ARRB1:active MAPKs:active SRC-1 [plasma membrane] [Complex:R-MMU-418103] F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] [Complex:R-MMU-418179] F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] [Complex:R-MMU-5218636] VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] [Complex:R-MMU-5218641] VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] [Complex:R-MMU-5218775] VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] [Complex:R-MMU-5218757] VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] [Complex:R-MMU-4420169] VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane]
(activeUnit)	[CatalystActivity:10014298] protein tyrosine kinase activity of F2R:ARRB1:MAPKs:active SRC-1 [plasma membrane] [CatalystActivity:10052761] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
(input)	[Reaction:R-MMU-418170] F2R:ARRB1 binds MAPKs, SRC-1 [Reaction:R-MMU-418176] F2R:ARRB2 binds MAPKs, SRC-1 [BlackBoxEvent:R-MMU-418662] Src activation following P2Y purinoceptor activation [BlackBoxEvent:R-MMU-443418] GP1b signaling involves c-Src [Reaction:R-MMU-5218645] SRC-1 binds p-Y397-PTK2 [Reaction:R-MMU-191654] c-src associates with Cx43 in gap junctions [Reaction:R-MMU-4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-418145] Activated SRC-1 [cytosol] [EntityWithAccessionedSequence:R-HSA-191648] SRC-2 [cytosol] [EntityWithAccessionedSequence:R-HSA-354153] SRC-1 [cytosol]
(hasMember)	[DefinedSet:R-MMU-8855753] SRC-1, RAP1GAP [cytosol] [DefinedSet:R-MMU-418805] SRC,FYN [cytosol] [DefinedSet:R-MMU-3928486] SRC,FYN,YES,LYN [cytosol] [DefinedSet:R-MMU-211064] Src family tyrosine kinases (SFKs) [cytosol] [DefinedSet:R-MMU-1861597] Src family kinases (SFKs) [cytosol]
(physicalEntity)	[CatalystActivity:10009964] protein tyrosine kinase activity of SRC-1 [cytosol] [CatalystActivity:10082298] protein tyrosine kinase activity of SRC-1 [cytosol]

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