Reactome | Complement cascade

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Complement cascade Show undefined attributes

compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099287
displayName	Complement cascade
eventOf	[Pathway:R-MMU-168249] Innate Immune System - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23216] complement activation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-MMU-166663] Initial triggering of complement - Mus musculus [Pathway:R-MMU-174577] Activation of C3 and C5 - Mus musculus [Pathway:R-MMU-166665] Terminal pathway of complement - Mus musculus [Pathway:R-MMU-977606] Regulation of Complement cascade - Mus musculus
inferredFrom	[Pathway:R-HSA-166658] Complement cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	Complement cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-166658
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-168249] Innate Immune System
(inferredTo)	[Pathway:R-HSA-166658] Complement cascade