Reactome | activated thrombin (factor IIa) [extracellular region]

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activated thrombin (factor IIa) [extracellular region] Show undefined attributes

catalystActivities	[CatalystActivity:9993243] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-MMU-429532] GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] - Mus musculus [Complex:R-MMU-5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region] - Mus musculus
consumedByEvent	[Reaction:R-MMU-429529] Thrombin binding to GP1b:IX:V - Mus musculus [Reaction:R-MMU-9603302] Factor IIa inhibitors (peptide) bind IIa - Mus musculus [Reaction:R-MMU-9015379] Factor IIa inhibitors (compounds) binds IIa - Mus musculus [Reaction:R-MMU-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) - Mus musculus [Reaction:R-MMU-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - Mus musculus [Reaction:R-MMU-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin - Mus musculus [Reaction:R-MMU-389463] Proteinase-activated receptors can bind thrombin - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9993242
displayName	activated thrombin (factor IIa) [extracellular region]
hasComponent	6 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [EntityWithAccessionedSequence:R-MMU-140589] F2 [extracellular region] [EntityWithAccessionedSequence:R-MMU-140598] F2 [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-156786] activated thrombin (factor IIa) [extracellular region] - Homo sapiens
maxDepth	2
memberOf	[CandidateSet:R-MMU-8852723] Activated thrombin, (ELANE) [extracellular region] - Mus musculus [DefinedSet:R-MMU-791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - Mus musculus
name	activated thrombin (factor IIa)
producedByEvent	[Reaction:R-MMU-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - Mus musculus [Reaction:R-MMU-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-156786
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-MMU-429529] Thrombin binding to GP1b:IX:V [Reaction:R-MMU-9603302] Factor IIa inhibitors (peptide) bind IIa [Reaction:R-MMU-9015379] Factor IIa inhibitors (compounds) binds IIa [Reaction:R-MMU-5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) [Reaction:R-MMU-140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Reaction:R-MMU-141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin [Reaction:R-MMU-389463] Proteinase-activated receptors can bind thrombin
(hasComponent)	[Complex:R-MMU-429532] GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] [Complex:R-MMU-140874] thrombin:cleaved SERPINC1 [extracellular region] [Complex:R-MMU-5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region] [Complex:R-MMU-9603322] Factor IIa inhibitors (peptide):IIa [extracellular region] [Complex:R-MMU-9015343] Factor IIa inhibitors (compounds):IIa [extracellular region] [Complex:R-MMU-389470] Thrombin:Proteinase-activated receptors [plasma membrane]
(output)	[Reaction:R-MMU-140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) [Reaction:R-MMU-140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
(hasMember)	[CandidateSet:R-MMU-8852723] Activated thrombin, (ELANE) [extracellular region] [DefinedSet:R-MMU-791492] Ligands of GPCRs that activate Gq/11 [extracellular region]
(physicalEntity)	[CatalystActivity:9993243] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
(inferredTo)	[Complex:R-HSA-156786] activated thrombin (factor IIa) [extracellular region]

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