Reactome | serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]

Schema > CatalystActivity > Entries

activity	[GO_MolecularFunction:1683] serine-type endopeptidase activity
catalyzedEvent	[Reaction:R-MMU-9708859] Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it - Mus musculus [Reaction:R-MMU-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - Mus musculus [Reaction:R-MMU-140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - Mus musculus [Reaction:R-MMU-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Mus musculus [Reaction:R-MMU-9930792] factor Va intermediate -> factor Va - Mus musculus [Reaction:R-MMU-9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) - Mus musculus [Reaction:R-MMU-140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - Mus musculus [Reaction:R-MMU-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Mus musculus [Reaction:R-MMU-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9993243
displayName	serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
physicalEntity	[Complex:R-MMU-156786] activated thrombin (factor IIa) [extracellular region]
schemaClass	CatalystActivity

(catalystActivity)

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