Reactome | Salvage - BH2 is reduced to BH4 by Dhfr

Schema > Reaction > Entries

authored	[InstanceEdit:1497774] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:1497849] dihydrofolate reductase activity of Dhfr dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
dbId	1497770
displayName	Salvage - BH2 is reduced to BH4 by Dhfr
edited	[InstanceEdit:1497774] Jassal, B, 2011-08-17
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-1497857] q-BH2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1497799] Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Salvage - BH2 is reduced to BH4 by Dhfr
orthologousEvent	[Reaction:R-HSA-1497794] Salvage - BH2 is reduced to BH4 by DHFR - Homo sapiens
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1497770
summation	[Summation:1497804] In the second salvage step, dihydrofolate reductase (DHFR) c...

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