Salvage - BH2 is reduced to BH4 by Dhfr

Stable Identifier
R-MMU-1497770
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Salvage - BH2 is reduced to BH4 by Dhfr

In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

Participants
Catalyst Activity

dihydrofolate reductase activity of Dhfr dimer [cytosol]

Orthologous Events
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