Reactome | Salvage - BH2 is reduced to BH4 by DHFR

Schema > Reaction > Entries

Salvage - BH2 is reduced to BH4 by DHFR Show undefined attributes

authored	[InstanceEdit:1497960] Jassal, B, 2011-08-17
catalystActivity	[CatalystActivity:1497819] dihydrofolate reductase activity of DHFR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1497774] Jassal, B, 2011-08-17
dbId	1497794
displayName	Salvage - BH2 is reduced to BH4 by DHFR
edited	[InstanceEdit:1497960] Jassal, B, 2011-08-17
eventOf	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Homo sapiens
inferredFrom	[Reaction:R-MMU-1497770] Salvage - BH2 is reduced to BH4 by Dhfr - Mus musculus
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-1497857] q-BH2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1497799] Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Salvage - BH2 is reduced to BH4 by DHFR
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-1497869] Salvage - Sepiapterin is reduced to q-BH2 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1502545] D'Eustachio, P, 2011-08-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1497794
summation	[Summation:1497804] In the second salvage step, dihydrofolate reductase (DHFR) c...

Referrals

(hasEvent)	[Pathway:R-HSA-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(inferredTo)	[Reaction:R-MMU-1497770] Salvage - BH2 is reduced to BH4 by Dhfr

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